Fig. 3

Gene expression analysis. a The relative expression of miR-218 level in MDA-MB-231 cells compared to normal MCF10A cells. b The relative expression of Runx2 in MDA-MB-231 cells compared to normal MCF10A cells. c The relative expression of Rictor in MDA-MB-231 cells compared to normal MCF10A cells. The expression of miR-218 (d), Runx2 (e) Rictor (f) in The Cancer Genome Atlas (TCGA) of breast cancer samples in UALCAN database. g The relative expression of miR-218 level in MDA-MB-231 cells treated with miR-218 containing ADMSC-exosomes and their controls determined by qRT-PCR. The relative expression of Runx2 (h), Rictor (i), E-cadherin (CDH1) and N-cadherin (CDH2) (j), and VEGF(k) mRNA levels in MDA-MB-231 cells treated with miR-218 containing ADMSC-exosomes and their controls determined by qRT-PCR. The data are presented as mean ± SD (*p value < 0.05, **p value < 0.001, and ***p < 0.0001, ****p < 0.00001)