Fig. 4

miR-218 containing exosomes reduce viability of MDA-MB-231 cells in vitro. a Bar graphs showing the MTT assay for analyzing the effect of miR-218 containing exosomes on the viability of MDA-MB-231 cells. b Representative dot plots showing the percentage of apoptotic cells in MDA-MB-231 cells 48 h and 72 h after treatment with miR-218 containing exosomes and their controls, detected by Annexin V/PI flow cytometry assay. c Bar graphs showing the apoptotic index detected by Annexin V/PI flow cytometry assay represented in (b), shown as mean ± SD from 3 independent experiments. (*p < 0.05, and *** p < 0.0001)