Fig. 6

miR-218 containing exosomes reduce angiogenic capacity of MDA-MB-231 cells. a Bar graphs showing the MTT assay for analyzing the effect of miR-218 containing exosomes on the viability and proliferation of HUVECs. b Representative photomicrographs showing the transwell migration assay of HUVECs after incubation with CM of exosome-treated MDA-MB-231 cells. c Bar graphs showing the significant decrease in migration of the cells incubated with CM of miR‐218 treated MDA-MB-231 cells. d Representative photomicrographs showing the tube formation of HUVECs treated with CM of exosome-treated MDA-MB-231 cells. e–f Bar graphs showing the number of meshes and total branching length were analyzed about the blood vessel formation that showed significant decrease in HUVECs treated with CM of exosome-treated MDA-MB-231 cells. Data are shown as mean ± SD from 3 independent experiments. (*p < 0.05, **p < 0.001, and ***p < 0.0001, ****p< 0.00001)