Table 1 Characteristics of the patients at baseline
Characteristics | Roxadustat (n = 106) | ESA (n = 53) | P value |
|---|---|---|---|
Male sex, n (%) | 59 (55.66) | 27 (50.94) | 0.574 |
Age, years | 47.59 ± 13.63 | 50.15 ± 12.02 | 0.248 |
BMI, kg/cm2 | 23.58 ± 3.66 | 24.80 ± 4.01 | 0.056 |
Weight, kg | 65.20 ± 12.59 | 66.91 ± 12.85 | 0.399 |
Duration of PD, weeks | 83.50 (40.00,120.75) | 90.00 (36.50,209.50) | 0.207 |
Mean arterial pressure, mmHg | 108.79 ± 17.61 | 105.86 ± 17.36 | 0.323 |
History of hypertension, n (%) | 94(88.68) | 45(84.91) | 0.499 |
History of diabetes mellitus, n (%) | 20(18.87) | 10(18.87) | 1.000 |
Peritoneal transport type: | |||
High transport, n (%) | 8 (7.55) | 3 (5.66) | 0.970 |
High average transport, n (%) | 25 (23.58) | 11 (20.75) | |
Low transport, n (%) | 8 (7.55) | 5 (9.43) | |
Low average transport, n (%) | 41 (38.68) | 22 (41.51) | |
Unknown, n (%) | 24 (22.64) | 12 (22.64) | |
Protopathy: | |||
Chronic glomerulonephritis, n (%) | 39 (36.79) | 21 (39.62) | 0.989 |
Polycystic kidney, n (%) | 8 (7.55) | 3 (5.66) | |
Hypertension, n (%) | 30 (28.30) | 14 (26.42) | |
Diabetes, n (%) | 18 (16.98) | 9 (16.98) | |
Nephrotic syndrome, n (%) | 6 (5.66) | 4 (7.55) | |
Others, n (%) | 5 (4.72) | 2 (3.77) | |
sTFR, nmol/L | 36.89 ± 10.06 | 36.50 ± 10.78 | 0.824 |
Hepcidin, ng/mL | 104.69 ± 27.41 | 100.66 ± 27.68 | 0.385 |
SI, µmol/L | 13.54 ± 6.46 | 12.80 ± 5.39 | 0.474 |
sFt, ng/mL | 215.80(71.96,354.95) | 195.90(83.93,354.60) | 0.801 |
TSAT, (%) | 32.13 ± 15.23 | 31.98 ± 14.85 | 0.952 |
TIBC, µmol/L | 43.33 ± 11.44 | 42.44 ± 12.03 | 0.653 |
RBC, 1012/L | 2.95 ± 0.38 | 2.89 ± 0.40 | 0.421 |
Hemoglobin, g/L | 87.84 ± 9.42 | 86.66 ± 10.72 | 0.479 |
EPO, mIU/mL | 6.40 (3.77, 9.05) | 5.64 (3.79, 9.36) | 0.949 |
K+, mmol/L | 4.27 ± 0.75 | 4.34 ± 0.80 | 0.595 |
> 5.5 mmol/L, n (%) | 4 (3.77) | 5 (9.43) | 0.145 |
HCO3−— mmol/L | 21.67 ± 3.50 | 21.85 ± 3.59 | 0.774 |
< 22.0 mmol/L, n (%) | 51 (48.11) | 24 (45.28) | 0.736 |
Total cholesterol, mmol/L | 4.01 ± 1.20 | 4.23 ± 1.14 | 0.277 |
Triglyceride, mmol/L | 1.54 ± 0.85 | 1.78 ± 1.33 | 0.156 |
HDL-C, mmol/L | 0.91 ± 0.32 | 0.93 ± 0.30 | 0.686 |
LDL-C, mmol/L | 2.43 ± 1.00 | 2.53 ± 0.97 | 0.549 |
C-reactive protein, mg/L | 2.00 (0.50, 6.32) | 2.41 (0.60, 5.80) | 0.703 |
> 4.9 mg/L, n (%) | 30 (28.30) | 16 (30.19) | 0.805 |
eGFR, mL/min | 6.33 (4.82, 8.09) | 5.48 (4.04, 7.00) | 0.069 |
Creatinine, µmol/L | 820.92 ± 216.48 | 883.87 ± 302.90 | 0.134 |