Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study)

Table 1 Patient characteristics

Characteristics, N = 83
Age	61 (52–69)
Sex, female	28 (34)
BMI	26 (23–31)
Comorbidities
Cardiovascular disease	43 (52)
Diabetes	29 (35)
Peripheral vascular disease	10 (12)
COPD	8 (9.6)
Chronic kidney disease	6 (7.2)
Malignancy	5 (6)
Immune deficiency	3 (3.6)
Rheumatoid disease	3 (3.6)
Liver cirrhosis	2 (2.4)
Disease severity measures
Septic shock on admission	34 (41)
SAPS II*	43 (35 −48)
SOFA, day 1†	8 (6–9)
LRINEC‡	8 (6–9)
Prognosis
Days hospitalized in the intensive care unit	9 (5–14)
Amputation within seven days	10 (12)
Mortality, day 90§	11 (13)

Continuous data are presented as medians (IQR) and categorical data as absolute numbers (percentage)
BMI body mass index, COPD chronic obstructive pulmonary disease, septic shock on admission, defined as lactate > 2 mmol/L and use of vasopressor or inotrope, LRINEC Laboratory Risk Indicator for Necrotizing Fasciitis Score, NSTI necrotizing soft-tissue infection, SAPS II Simplified Acute Physiology Score II, SOFA Sequential Organ Failure Assessment
^*Data were missing for two (2.4%) patients
^†Data were missing for two (2.4%) patients
^‡Data were missing for 11 (13.3%) patients
^§Data were missing for one (1.2%) patient

ISSN: 2047-783X