Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer

Table 3 Univariate and multivariate Cox regression analyses of prognostic covariates (overall survival) in patients with CRC

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
Characteristics	Total (N)	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
N stage	639
N0	367	Reference
N1	153	1.774 (1.131–2.781)	0.013	0.021 (0.001–0.507)	0.017
N2	119	3.873 (2.588–5.796)	< 0.001	0.024 (0.001–0.592)	0.022
M stage	563
M0	474	Reference
M1	89	3.989 (2.684–5.929)	< 0.001	2.083 (0.516–8.404)	0.302
Pathologic stage	622
Stage I & Stage II	348	Reference
Stage III & Stage IV	274	2.988 (2.042–4.372)	< 0.001	83.444 (2.290–3040.287)	0.016
Age	643
≤65	276	Reference
>65	367	1.939 (1.320–2.849)	< 0.001	3.738 (0.794–17.602)	0.095
BMI	329
<25	107	Reference
≥25	222	0.649 (0.394–1.069)	0.090	0.715 (0.200–2.555)	0.605
CEA level	414
≤5	260	Reference
>5	154	2.620 (1.611–4.261)	< 0.001	0.865 (0.206–3.627)	0.842
Residual tumor	509
R0	467	Reference
R1 & R2	42	4.609 (2.804–7.577)	< 0.001	68.163 (6.142–756.470)	< 0.001
Lymphatic invasion	581
No	349	Reference
Yes	232	2.144 (1.476–3.114)	< 0.001	3.049 (0.686–13.557)	0.143
GRID2IP	643
Low	321	Reference
High	322	1.486 (1.047–2.109)	0.027	1.147 (0.305–4.316)	0.839

The Hazard ratio of the Reference group is the Reference and the other groups is compared with the reference group to obtain the HR value

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