Table 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of integrated DEGs
Pathway | ID | Gene count | Log P-value | Genes |
|---|---|---|---|---|
Up-regulated KEGG | ||||
Wnt signaling pathway | hsa04310 | 7 | − 2.82093 | NFATC4,ROR2,TCF7,AXIN2, BAMBI,WNT5B,NOTUM |
Protein digestion and absorption | hsa04974 | 10 | − 7.48275 | COL3A1,COL11A1,COL11A2,COL13A1,SLC8A2, XPNPEP2,KCNK5,SLC7A7,COL22A1,COL24A1 |
Nitrogen metabolism | hsa00910 | 3 | − 3.15626 | CA6,CA9,CA12 |
Rap1 signaling pathway | hsa04015 | 8 | − 2.69188 | FGFR4,FLT4,KDR,KRAS,PFN2, F2RL3,FARP2,LPAR3 |
PI3K-Akt signaling pathway | hsa04151 | 12 | − 3.35898 | CDK6,COMP,FGFR4,FLT4,IBSP,KDR, KRAS,LAMA4,THBS3,LPAR3,TNN,CREB3L3 |
Human papillomavirus infection | hsa05165 | 11 | − 3.08673 | CDK6,COMP,IBSP,KRAS,LAMA4,TCF7, THBS3,AXIN2,TNN,WNT5B,CREB3L3 |
Focal adhesion | hsa04510 | 8 | − 2.85175 | COMP,FLT4,IBSP,KDR,LAMA4, THBS3,SHC2,TNN |
ECM-receptor interaction | hsa04512 | 5 | − 2.78273 | COMP,IBSP,LAMA4,THBS3,TNN |
Pathways in cancer | hsa05200 | 15 | − 3.17301 | BDKRB1,BDKRB2,BMP2,CDK6,FGFR4,FLT4, IL13RA1,KRAS,LAMA4,PTCH1,TCF7,AXIN2, F2RL3,LPAR3,WNT5B |
Basal cell carcinoma | hsa05217 | 5 | − 3.15797 | BMP2,PTCH1,TCF7,AXIN2,WNT5B |
Breast cancer | hsa05224 | 7 | − 2.92668 | CDK6,FLT4,KRAS,TCF7,AXIN2, SHC2,WNT5B |
Cushing syndrome | hsa04934 | 6 | − 2.14083 | CDK6,PDE8A,TCF7,AXIN2, WNT5B,CREB3L3 |
Hepatocellular carcinoma | hsa05225 | 6 | − 2.01463 | CDK6,KRAS,TCF7,AXIN2, SHC2,WNT5B |
Cytokine-cytokine receptor interaction | hsa04060 | 10 | − 2.775 | AMHR2,BMP2,FLT4,CXCL3,IL13RA1,KDR, TNFRSF11B,CXCL14,CXCR6,IL17D |
TGF-beta signaling pathway | hsa04350 | 5 | − 2.6331 | AMHR2,BMP2,DCN,FMOD,BAMBI |
Chemokine signaling pathway | hsa04062 | 7 | − 2.38828 | CXCL3,KRAS,NFKBIB,CXCL14, CXCR6,SHC2,PREX1 |
Biosynthesis of amino acids | hsa01230 | 4 | − 2.18385 | CTH,ENO2,PGAM2,PYCR1 |
cGMP-PKG signaling pathway | hsa04022 | 6 | − 2.11711 | ATP2A1,BDKRB2,KCNMA1,NFATC4, SLC8A2,CREB3L3 |
Down-regulated KEGG | ||||
Neuroactive ligand-receptor interaction | hsa04080 | 10 | − 4.7048802 | ADCYAP1R1,ADM,AGT,AVPR1A,C3AR1, S1PR3,F2R,GABRA4,PRL,CALCRL |
Pathways in cancer | hsa05200 | 10 | − 3.1714531 | AGT,CEBPA,COL4A1,COL4A2,F2R,HGF, IL5,MGST1,MGST3,CXCL12 |
Cytokine-cytokine receptor interaction | hsa04060 | 8 | − 3.5862507 | HGF,IL5,PRL,CCL2,CCL7,CCL15,CXCL11, CXCL12 |
PI3K-Akt signaling pathway | hsa04151 | 8 | − 3.1640003 | ANGPT1,COL4A1,COL4A2,ERBB4,F2R, HGF,PRL,SPP1 |
AGE-RAGE signaling pathway in diabetic complications | hsa04933 | 6 | − 4.7698524 | AGT,COL4A1,COL4A2,F3, SERPINE1,CCL2 |
Chemokine signaling pathway | hsa04062 | 5 | -2.4473282 | CCL2,CCL7,CCL15,CXCL11, CXCL12 |
NOD-like receptor signaling pathway | hsa04621 | 5 | − 2.6008533 | CASP1,DEFA1,IFI16, MEFV,CCL2 |
Vascular smooth muscle contraction | hsa04270 | 5 | − 3.1886762 | ADM,AGT,AVPR1A, CALCRL,KCNMB4 |
Phospholipase D signaling pathway | hsa04072 | 4 | − 2.023575 | AGT,AVPR1A,F2R,PIP5K1B |
Complement and coagulation cascades | hsa04610 | 4 | − 2.9382136 | C3AR1,F2R,F3,SERPINE1 |
Chemical carcinogenesis | hsa05204 | 4 | − 2.9741296 | CYP1B1,MGST1,MGST3, SULT1A1 |
PPAR signaling pathway | hsa03320 | 4 | − 3.0297181 | LPL,ADIPOQ,NR1H3,PLIN4 |
ECM-receptor interaction | hsa04512 | 3 | − 2.030843 | COL4A1,COL4A2,SPP1 |
Ovarian steroidogenesis | hsa04913 | 3 | − 2.5731323 | CYP1B1,CYP2J2,AKR1C3 |
Arachidonic acid metabolism | hsa00590 | 3 | − 2.4057499 | CYP2J2,EPHX2,AKR1C3 |
Metabolism of xenobiotics by cytochrome P450 | hsa00980 | 3 | − 2.1782063 | CYP1B1,MGST1,MGST3 |