Fig. 1

Canonical a and non-canonical b Hippo signaling pathways. FAT4, atypical cadherin 4; GPCR, G protein coupled receptor; FGFR4, fibroblast growth factor receptor 4; TLR, Toll-like receptor; TCR, T-cell receptor; BCR, B cell receptor; CaMK II, calmodulin-dependent protein kinase II; IRAK1/4, interleukin-1 receptor-related kinase 1/4; NF-κB, nuclear factor κB; PKC, protein kinase C; RAP1, Ras protein 1; RAPL, Ras protein ligand; Rassf5b, Ras-related domain family 5b; LFA-1, lymphocyte function-related antigen 1; DOCK8, cytokinesis factor 8; Rac1, Rac family guanosine triphosphate 1; Keap1, Kelch class ECH-related protein l; AKT, protein kinase B; Sirt1, Sirtuin1; Stat5, signal converting and transcriptional activating protein 5; ROS, reactive oxygen; Nrf2, erythrocyte-like-related factor 2; IRF3, interferon regulatory factor 3; Foxo1/3, fork head box protein O1/3; Foxp3, fork head box protein P3; RORγt, retinoic acid-related orphan receptor γt