Fig. 2

Mst1/2-TAZ signal regulates the differentiation of Th17 and Treg. During the differentiation of Th17 and Treg cells, TGF-β induces the expression, and IL-6 further increases the expression. As a transcription coactivator, TAZ can enhance the core transcription factor RORγt in Th17 cells to promote their development and differentiation of Th17. TAZ can also promote the degradation of Foxp3 and inhibit the differentiation of Tregs by regulating the acetylation and ubiquitination levels of Foxp3, the core transcription factor of Tregs. Therefore, the Hippo pathway regulates homeostasis of immune inflammation and tolerance