Fig. 3
From: The role of non-canonical Hippo pathway in regulating immune homeostasis
Molecular mechanism of Mst1/2 regulating macrophage anti-infection and maintaining cell redox homeostasis. Under the condition of bacterial infection, TLR in macrophages combined with the mechanical sensitive receptor Piezo1 activates Mst1/2, activates Rac1, promotes mitochondria to collect around phagosomes to produce lethal ROS, and enhances NADPH oxidase activity on phagosome cell membranes to produce more lethal ROS, ultimately killing bacteria. A large amount of ROS further activates Mst1/2, regulates the stability of Nrf2 through phosphorylation of Keap1, promotes the expression of antioxidant genes, and realizes the antioxidant stress response of cells. Therefore, the Hippo pathway plays an important role in regulating redox homeostasis in macrophages