Fig. 3

Genomic characteristics of high-risk and low-risk EOCRC samples. Differences in TMB (A), CNA fraction (B), and aneuploidy score (C) between high-risk and low-risk samples. D Heatmap depicting differentially mutated genes with mutation frequencies not less than 10% in the TCGA. E Difference in the frequency of POLE mutation between high-risk and low-risk samples. F Difference in the amplification and deletion of CNA between high-risk and low-risk samples. Amp-L, amplification in low-risk samples; Del-H, deletion in high-risk samples; Del-L, deletion in low-risk samples; ****p < 0.0001. G Histograms depicting the proportion of different CNA statuses of CTLA4 and POLD1 in high-risk and low-risk samples. Amp, amplification; Del, deletion; neutral, no change