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Table 3 Comparison of 18F-FAPI and 18F-FDG in the evaluation of small mediastinal and hilar lymph nodes

From: 18F-FAPI PET/CT performs better in evaluating mediastinal and hilar lymph nodes in patients with lung cancer: comparison with 18F-FDG PET/CT

 

18F-FAPI

18F-FDG

P value

True positive (No. of lymph nodes)

10

10

/

False positive (No. of lymph nodes)

3

20

/

False negative (No. of lymph nodes)

3

3

/

True negative (No. of lymph nodes)

69

52

/

Sensitivity (%)

77 [49, 93]

77 [49, 93]

NS

Specificity (%)

96 [88, 99]

72 [61, 81]

 < .001*

Accuracy (%)

93 [85, 97]

73 [63, 81]

 < .001*

PPV (%)

77 [49, 93]

33 [19, 51]

/

NPV (%)

96 [88, 99]

95 [84, 98]

/

  1. Data in brackets are 95% CIs. FAPI fibroblast activation protein inhibitor, FDG = fluorodeoxyglucose, 18F  fluorine 18, PPV positive predictive value, NPV negative predictive value, NS  no statistics significance
  2. *Indicates statistical significance