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Table 1 Comparison of baseline characteristics and outcomes of patients with different types of HT

From: Prediction factors and clinical significance of different types of hemorrhagic transformation after intravenous thrombolysis

Variables

Control (12127)

HI (541)

PH (440)

P Value

Age (year)

70 (60–79)

76 (68–82)

78.5 (71–84)

 < 0.001

Male, %

7532 (62.1)

314 (58.0)

254 (57.7)

0.033

Medical history

 Hypertension, %

7884 (65.0)

363 (67.1)

300 (68.2)

0.250

 Diabetes mellitus, %

2037 (16.8)

92 (17.0)

65 (14.8)

0.529

 Hypercholesterolemia, %

740 (6.1)

26 (4.8)

26 (5.9)

0.460

 Atrial fibrillation, %

1793 (14.8)

178 (32.9)

153 (34.8)

 < 0.001

 Previous ischemic stroke, %

1572 (13.0)

70 (12.9)

69 (15.7)

0.252

 Smoking, %

3031 (25.0)

111 (20.5)

84 (19.1)

0.001

Prior drugs use

 Prior antiplatelet use, %

1749 (14.4)

92 (17.0)

94 (24.1)

 < 0.001

 Prior anticoagulant use, %

169 (1.4)

15 (2.8)

11 (2.5)

0.008

 Prior statin use, %

1154 (9.5)

43 (7.9)

54 (12.3)

0.068

 Baseline systolic pressure (mmHg)

154 (140–168)

158 (140–172)

157 (143–170)

0.001

 Baseline diastolic pressure (mmHg)

85 (76–94)

86 (77–96)

86 (78–95)

0.006

 Baseline NIHSS score

5 (2–9)

11 (5–16)

12 (6–18)

 < 0.001

 OTT (min)

149 (108–196)

157 (115–207)

155 (110–206)

0.009

 Remote hemorrhage

NA

163 (30.1)

249 (56.6)

 < 0.001

Fibrinolytic drug

   

0.519

 rt-PA, %

11920 (98.3)

534 (98.7)

435 (98.9)

 

 Urokinase, %

207 (1.7)

7 (1.3)

5 (1.1)

 

7d mortality, %

271 (2.2)

42 (7.8)

115 (26.1)

 < 0.001

Stroke recurred at discharge, %

222 (1.8)

11 (2.0)

26 (5.9)

 < 0.001

Stroke recurred at 3 m, %

184 (1.5)

6 (1.1)

3 (0.7)

0.259

mRS score at 90d

1 (0–3)

3 (1–5)

5 (3–6)

 < 0.001

  1. HI hemorrhagic infarction, PH parenchymal hemorrhage, OTT onset to treatment time, mRS modified Rankin Scale. Bold text indicates a p-value < 0.05