Table 1 Summary of methodology for this review
Methodology steps | Description |
|---|---|
Literature search | PubMed, EMBASE, Google Scholar, the Cochrane Library, and Scopus |
Inclusion criteria | Full-text articles published in English Publication date range: 2003–2023 (past two decades) Focus on neurosurgery and neurology |
Exclusion criteria | Standalone abstracts Case reports Posters Unpublished or non-peer-reviewed studies |
Search terms | Keywords such as “scRNA Sequencing” and “Single-cell sequencing” coupled with indicators, such as “Brain Tumours”, “Spinal Cord Tumours”, “Neurodegenerative Disorders”, “Cerebrovascular Disorders”, “strokes”, and “epilepsy” |
Additional search | Manual examination of references cited in recent disease-specific reviews No predetermined limit on the number of studies Encompassing diverse study designs: • Descriptive studies • Animal-model studies • Cohort studies • Observational studies Including investigations in both pre-clinical and clinical settings |