Fig. 9

TIMELESS-related gene enrichment analysis. a We first obtained the available experimentally determined TIMELESS-binding proteins using the STRING tool. b Using the GeneMANIA to predict the functional network of TIMELESS. c Intersection analysis of the TIMELESS-binding and correlated genes was conducted. d The corresponding heatmap data in the detailed cancer types are displayed between TIMELESS and selected targeting genes, including CDC7, MCM2, MCM3, MCM6, MCM8, and GINS1. e Using the GEPIA2 approach, we also obtained the top 100 TIMELESS-correlated genes in TCGA projects and analyzed the expression correlation between TIMELESS and selected targeting genes, including MCM2, MCM6, GINS1, CDC7, MCM3 and MCM8. f Based on the TIMELESS-binding and interacted genes, The cnetplot for the biological process data in GO analysis is shown. g KEGG pathway analysis was also performed