Fig. 1

ATF6 attenuates hepatic steatosis in fatty liver by inducing H₂S accumulation. A H₂S level was analyzed in liver tissue of WT and ATF6^−/− mice fed on HFD. B H₂S level was analyzed in primary mouse hepatocytes. C Histology analysis of liver in WT, ATF6^−/−, and GYY4137 treated mice detected by HE stain (*200). D Glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were performed with/without GYY4137 treatment in ATF6^−/− mice on HFD. E Liver and serum triglyceride and cholesterol levels in ATF6^−/− mice with/without GYY4137 treatment. The asterisks (*) marked in the graph represents the significant differences (p* < 0.05; p** < 0.01; p*** < 0.001) in different groups. (n = 3–4 for each group)