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Fig. 3 | European Journal of Medical Research

Fig. 3

From: Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage

Fig. 3

ATF6 upregulates the promoter activity and expression of the CBS gene. A HepG2 were co-transfected with the CBS promoter luciferase plasmids and ATF6 plasmids. Luciferase assays of CBS were performed. B The binding sites of ATF6 was predicted by AliBaba 2.1. C EMSA assays was carried out to explore the Binding affinity of ATF6 to biotin-labeled probe of CBS. D The ChIP-qPCR assay was performed to detect the ATF 6 enrichment level on the CBS promoter. The asterisks (***) marked in the graph represents the significant differences (p*** < 0.001) in two groups

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European Journal of Medical Research

ISSN: 2047-783X

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