Fig. 4
ATF6 can promotes SIRT1 sulfhydration by H2S signal and regulate the inflammation response by mediating IL-10/IL-17A. A Effect of ATF6 on the protein expression of SIRT1 in vivo. B Effect of ATF6 on the protein expression of SIRT1 in vitro. C Effect of ATF6 on the mRNA expression of SREBP in ATF6−/− mice. D Effect of ATF6 on the mRNA expression of SREBP in HepG2 with ATF6 overexpression. E SREBP mRNA expression with DTT treatment. F The ATF6 effect on inflammatory cytokines. The asterisks (*) marked in the graph represents the significant differences (p* < 0.05; p*** < 0.001) in different groups. (n = 9 for each group). WT wildtype, NC negative control