A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology

Table 3 Functional roles of ELOVL family members in cellular pathways and diseases

ELOVL family member	Associated pathways and functions	References
ELOVL1	Affects immune cell infiltration, immune checkpoint markers such as PD-1 and CTLA-4 in HCC	Zhang et al. [69]
ELOVL2	Associated with key aging-associated pathways	Li et al. [28]
ELOVL3	Plays roles downstream of MAPK, mTOR, and Wnt signaling pathways	Wei et al. [65]
ELOVL4	Involved in neuroprotective signaling for photoreceptor cell integrity	Yeboah et al. [68]
ELOVL5	Knockout inhibits AKT Ser473 phosphorylation, suppresses renal cancer cell invasion through AKT-mTOR-STAT3 signaling	Nitta et al. [44]
ELOVL6	Depletion induces a repair-promoting phagocyte phenotype through S1P/PPARγ pathway	Garcia et al. [16]
ELOVL7	Enriched KEGG pathways including PI3K-Akt signaling, lysosome, HIF, Wnt, and AMPK signaling	Risha et al. [49]

PD-1, programmed cell death-1; CTLA-4, cytotoxic T lymphocyte-associated protein-4; HCC, hepatocellular carcinoma; MAPK, mitogen-activated protein kinases; mTOR, mammalian target of rapamycin; Wnt, wint; KEGG, kyoto encyclopedia of genes and genomes; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; STAT3, signal transducer and activator of transcription 3; S1P, sphingosine-1-phosphate; PPARγ, peroxisome proliferator-activated receptor γ

ISSN: 2047-783X