A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology

Table 4 Tissue-specific roles of ELOVL family members in lipid metabolism

Tissue	ELOVL family member	Role and function	References
Brain	ELOVL4	Critical for brain development and function	Ellezam et al. [13]
Skin	ELOVL1	Crucial for skin barrier function, contributes to ceramide synthesis and skin hydration, protection, and barrier integrity	Sassa et al. [53]
Liver	Various ELOVL isoforms	Associated with hepatic lipid metabolism, contribute to lipid droplet formation, triglyceride synthesis, and lipid export	Matsuzaka et al. [34, 35]

ISSN: 2047-783X