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Table 2 Incidences and hazard ratios of herpes zoster for individuals with and without fatty liver by age, sex and comorbidity

From: Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Variables

Herpes zoster

cHR

(95% CI)

aHR

(95% CI)

n

PY

IR

Fatty liver

 No

4211

530,032

7.94

1.00

(reference)

1.00

(reference)

 Yes

5346

557,454

9.59

1.14

(1.09, 1.19)***

1.06

(1.02, 1.10)***

Fatty liver

 Alcoholic fatty liver

506

66,309

7.63

1.00

(reference)

1.00

(reference)

 Non-alcoholic fatty liver

4840

491,144

9.85

1.41

(1.29, 1.55)***

1.22

(1.11, 1.33)***

Sex

 Female

4853

449,245

10.80

1.00

(reference)

1.00

(reference)

 Male

4704

638,240

7.37

0.68

(0.66, 0.71)***

0.94

(0.90, 0.98)***

Age, year

 20–29

310

90,330

3.43

1.00

(reference)

1.00

(reference)

 30–39

828

205,310

4.03

1.16

(1.02, 1.32)*

1.15

(1.01, 1.31)*

 40–49

1921

279,967

6.86

1.93

(1.71, 2.18)***

1.81

(1.61, 2.05)***

 50–59

3090

269,946

11.45

3.60

(3.20, 4.04)***

3.11

(2.77, 3.51)***

 60–69

2147

153,953

13.95

4.77

(4.24, 5.38)***

3.83

(3.39, 4.32)***

  > 69

1261

87,978

14.33

6.49

(5.73, 7.35)***

4.91

(4.32, 5.59)***

Comorbidities

 Diabetes mellitus

  No

6955

859,546

8.09

1.00

(reference)

1.00

(reference)

  Yes

2602

227,939

11.42

1.92

(1.83, 2.01)***

1.33

(1.27, 1.39)***

 Chronic kidney disease

  No

9376

1,072,661

8.74

1.00

(reference)

1.00

(reference)

  Yes

181

14,824

12.21

2.57

(2.22, 2.98)***

1.57

(1.35, 1.82)***

 Coronary artery disease

  No

7130

902,654

7.90

1.00

(reference)

1.00

(reference)

  Yes

2427

184,832

13.13

2.30

(2.19, 2.41)***

1.40

(1.33, 1.47)***

 Cancer

  No

9134

1,057,595

8.64

1.00

(reference)

1.00

(reference)

  Yes

423

29,890

14.15

2.34

(2.13, 2.59)***

1.70

(1.54, 1.88)***

 Obesity

  No

9270

1,055,219

8.78

1.00

(reference)

1.00

(reference)

  Yes

287

32,266

8.89

1.48

(1.31, 1.66)***

1.69

(1.50, 1.91)***

 Depression

  No

8628

999,558

8.63

1.00

(reference)

1.00

(reference)

  Yes

929

87,928

10.57

1.73

(1.62, 1.85)***

1.40

(1.31, 1.51)***

  1. PY: person-year; IR: incidence rate, per 1000 person-years; cHR: crude hazard ratio; aHR: adjusted hazard ratio, adjusted hazard ratio, adjusted for age, sex, index year and comorbidities; CI: confidence interval; *p < 0.05, ***p < 0.001
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European Journal of Medical Research

ISSN: 2047-783X

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