Table 3 Incidences and hazard ratios of herpes zoster by age, sex and comorbidity in alcoholic fatty liver and non-alcoholic fatty liver groups
Variables | Herpes zoster | cHR | (95% CI) | aHR | (95% CI) | ||
|---|---|---|---|---|---|---|---|
Event | PY | IR | |||||
Alcoholic fatty liver | |||||||
 Sex | |||||||
  Female | 208 | 19,111 | 10.88 | 1.00 | (reference) | 1.00 | (reference) |
  Male | 298 | 47,198 | 6.31 | 0.62 | (0.52, 0.74)*** | 0.83 | (0.69, 1.00) |
Age, year | |||||||
 20–29 | 11 | 5090 | 2.16 | 1.00 | (reference) | 1.00 | (reference) |
 30–39 | 53 | 15,259 | 3.47 | 1.74 | (0.91, 3.33) | 1.76 | (0.92, 3.37) |
 40–49 | 132 | 20,479 | 6.45 | 3.15 | (1.70, 5.82)*** | 2.97 | (1.60, 5.51)*** |
 50–59 | 170 | 15,894 | 10.70 | 5.54 | (3.01, 10.19)*** | 4.79 | (2.59, 8.85)*** |
 60–69 | 95 | 6609 | 14.37 | 7.97 | (4.27, 14.89)*** | 6.35 | (3.37, 11.99)*** |
  > 69 | 45 | 2978 | 15.11 | 10.00 | (5.19, 19.42)*** | 7.76 | (3.96, 15.22)*** |
Comorbidities | |||||||
 Diabetes mellitus | |||||||
  No | 391 | 55,367 | 7.06 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 115 | 10,945 | 10.51 | 2.12 | (1.72, 2.61)*** | 1.32 | (1.06, 1.65)* |
 Chronic kidney disease | |||||||
  No | 499 | 65,472 | 7.62 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 7 | 837 | 8.36 | 1.86 | (0.88, 3.93) | 1.18 | (0.56, 2.50) |
 Coronary artery disease | |||||||
  No | 395 | 57,494 | 6.87 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 111 | 8816 | 12.59 | 2.58 | (2.08, 3.19)*** | 1.49 | (1.19, 1.88)*** |
 Cancer | |||||||
  No | 496 | 65,300 | 7.60 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 10 | 1009 | 9.91 | 1.87 | (1.00, 3.49) | 1.37 | (0.73, 2.58) |
 Obesity | |||||||
  No | 487 | 65,018 | 7.49 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 19 | 1291 | 14.71 | 2.90 | (1.83, 4.59)*** | 3.00 | (1.86, 4.83)*** |
 Depression | |||||||
  No | 453 | 61,521 | 7.36 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 53 | 4789 | 11.07 | 2.13 | (1.60, 2.83)*** | 1.50 | (1.12, 2.02)** |
Non-alcoholic fatty liver | |||||||
 Sex | |||||||
  Female | 2488 | 211,826 | 11.75 | 1.00 | (reference) | 1.00 | (reference) |
  Male | 2352 | 279,318 | 8.42 | 0.72 | (0.68, 0.77)*** | 0.96 | (0.90, 1.02) |
Age, year | |||||||
 20–29 | 163 | 40,238 | 4.05 | 1.00 | (reference) | 1.00 | (reference) |
 30–39 | 414 | 87,785 | 4.72 | 1.13 | (0.94, 1.35) | 1.12 | (0.93, 1.34) |
 40–49 | 914 | 121,055 | 7.55 | 1.76 | (1.49, 2.08)*** | 1.66 | (1.40, 1.96)*** |
 50–59 | 1525 | 122,712 | 12.43 | 3.19 | (2.71, 3.75)*** | 2.79 | (2.37, 3.29)*** |
 60–69 | 1116 | 74,190 | 15.04 | 4.06 | (3.44, 4.78)*** | 3.32 | (2.81, 3.94)*** |
  > 69 | 708 | 45,165 | 15.68 | 5.37 | (4.53, 6.37)*** | 4.17 | (3.50, 4.98)*** |
Comorbidities | |||||||
 Diabetes mellitus | |||||||
  No | 3486 | 381,992 | 9.13 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 1354 | 109,154 | 12.40 | 1.77 | (1.66, 1.88)*** | 1.28 | (1.20, 1.36)*** |
 Chronic kidney disease | |||||||
  No | 4751 | 483,715 | 9.82 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 89 | 7430 | 11.98 | 2.10 | (1.70, 2.60)*** | 1.35 | (1.10, 1.67)** |
 Coronary artery disease | |||||||
  No | 3584 | 403,266 | 8.89 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 1256 | 87,878 | 14.29 | 2.18 | (2.04, 2.33)*** | 1.41 | (1.31, 1.51)*** |
 Cancer | |||||||
  No | 4606 | 475,585 | 9.68 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 234 | 15,559 | 15.04 | 2.02 | (1.77, 2.30)*** | 1.52 | (1.33, 1.74)*** |
 Obesity | |||||||
  No | 4703 | 475,681 | 9.89 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 137 | 15,463 | 8.86 | 1.29 | (1.09, 1.54)** | 1.53 | (1.29, 1.81)*** |
 Depression | |||||||
  No | 4388 | 450,667 | 9.74 | 1.00 | (reference) | 1.00 | (reference) |
  Yes | 452 | 40,478 | 11.17 | 1.62 | (1.47, 1.78)*** | 1.35 | (1.22, 1.49)*** |