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Table 4 Cox proportional hazards regression analysis for the risk of herpes zoster

From: Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Variables

Fatty liver

cHR (95% CI)

aHR (95% CI)

No

Yes

n

PY

IR

n

PY

IR

Sex

Female

2157

218,307

9.88

2696

230,937

11.67

1.11 (1.05, 1.17)***

1.06 (1.00, 1.12)

 Male

2054

311,724

6.59

2650

326,516

8.12

1.17 (1.10, 1.24)***

1.09 (1.03, 1.15)**

Age, year

 20–29

136

45,003

3.02

174

45,327

3.84

1.25 (1.00, 1.56)

1.24 (0.99, 1.55)

 30–39

361

102,266

3.53

467

103,044

4.53

1.26 (1.10, 1.44)**

1.24 (1.08, 1.42)**

 40–49

875

138,433

6.32

1046

141,534

7.39

1.12 (1.02, 1.22)*

1.10 (1.00, 1.20)*

 50–59

1395

131,340

10.62

1695

138,606

12.23

1.07 (0.99, 1.15)

1.05 (0.98, 1.13)

 60–69

936

73,154

12.79

1211

80,799

14.99

1.03 (0.95, 1.12)

1.01 (0.93, 1.10)

  > 69

508

39,835

12.75

753

48,144

15.64

0.98 (0.88, 1.10)

0.97 (0.86, 1.08)

Comorbidities

 No

2088

327,795

6.37

2661

335,404

7.93

1.18

(1.12, 1.25)***

1.14

(1.08, 1.21)***

 Yes

2123

202,236

10.50

2685

222,049

12.09

1.03 (0.98, 1.09)

0.98 (0.93, 1.04)

  1. aIndividuals with any comorbidity of diabetes mellitus, chronic kidney disease, coronary artery disease, cancer, obesity and depression were classified into the comorbidity group; PY: person-year; IR: incidence rate, per 1000 person-years; cHR: crude hazard ratio; aHR: adjusted hazard ratio, adjusted for age, sex, index year and comorbidities; CI: confidence interval; *p < 0.05, **p < 0.01, ***p < 0.001