Fig. 8

A Mapping of keywords in the research related to CAFs research from 1999 to 2021; the frequency is represented by point size and the keywords of research fields are divided into five clusters: tumor classification (red), prognostic study (yellow), oncologic therapies (green), tumor metabolism (blue), and tumor microenvironment (purple). B Distribution of keywords according to the mean frequency of appearance; keywords in yellow appeared later than those in blue