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Fig. 1 | European Journal of Medical Research

Fig. 1

From: RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68

Fig. 1

YTHDF1 was associated with AR, and androgen receptor (AR) inhibitor inhibited viability of prostatic cancer (PC) cells. A Significantly differentially expressed androgen-related genes. B Regulatory network of m6A genes and the differentially expressed androgen-related genes. Yellow nodes represent m6A genes, and the rest represent differentially expressed androgen-related genes. C Protein expression of YTHDF1 in the normal cells and PC cell lines detected by western blot. *P < 0.05, compared to RWPE-2; #P < 0.05, compared to LNCAP. D Cell viability of LNCAP after 48 h of treatment with different concentrations of AR inhibitor. *P < 0.05, ** P < 0.01, compared to the blank group. E mRNA expression levels of m6A-related genes detected by qRT-PCR. *P < 0.05, ** P < 0.01, compared to the control group. F Protein expression levels of AR and YTHDF1 detected by western blot. ARi treated group: AR inhibitor treated group

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European Journal of Medical Research

ISSN: 2047-783X

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