Fig. 5

TRIM68 reversed the effects of YTHDF1 knockdown in PC in vivo. Representative photos of tumors (A), tumor volume (B), tumor inhibition rate (C), H&E (D), immunohistochemistry (E) and TUNEL staining (F) in si-YTHDF1, si-TRIM68 and si-TRIM68 + OE-TRIM68 groups. Scale bar for H&E and immunohistochemistry was 200 μm; and scale bar for TUNEL staining was 50 μm. The m6A (G) and AR level (H) in nude mouse xenografts and serum in si-YTHDF1, si-TRIM68 and si-TRIM68 + OE-TRIM68 groups. *P < 0.05, **P < 0.01, compared to siNC group;^#P < 0.05, ^##P < 0.01, compared to YTHDF1 siRNA group; ^&P < 0.05, ^&&P < 0.01, compared to TRIM68 siRNA group