Fig. 3
From: Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials
Biological pathways for chronic lymphocytic leukemia pathogenesis and the suggested therapeutic targets. BCL2: B-cell lymphoma 2; BTK: Bruton’s tyrosine kinase; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; (NOTCH1): notch homolog 1 PEST: a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T) of the NICD: NOTCH intracellular domain; TP53: tumor protein 53; ATM: ataxia telangiectasia mutated proteins