Fig. 4
From: Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials
NOTCH signaling pathway. ADAM: metalloprotease (metalloproteinase/disintegrin/cysteine-rich); ICN1: intracellular domains of NOTCH1; MAML1 co-activator (Mastermind-like 1); PEST: peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T); HD: heterodimerization domain; LNR: lymph node ratio NOTCH1 activation shows: the interaction between the NOTCH1 receptor, Delta-like and Jagged ligands which are expressed on the surface of a near cells activating the proteolytic cleavage of the receptor; by an ADAM metalloprotease (metalloproteinase/disintegrin/cysteine-rich) (S2 cleavage) followed by the γ-secretase complex (S3 cleavage), which releases the intracellular domains of NOTCH1 (ICN1) from the membrane. ICN1 is transferred to the nucleus and interacts with DNA-binding protein and induces the MAML1 co-activator (Mastermind-like 1) to activate the expression of NOTCH1 target genes