Table 1 Major four types of leukemia types and manifestations
From: Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials
Name | Manifestations | References |
|---|---|---|
Acute lymphoblastic leukemia (ALL) | - Malignant transformation and proliferation of the lymphoid cells at an early stage of differentiation which could be able to invade the bone marrow, blood, and extramedullary sites - It represents a devastating disease when it occurs in adults as 80% of acute lymphoblastic leukemia occurs in children | |
Acute myeloid leukemia (AML) | - A malignant disorder of haemopoietic stem cells characterized by clonal expansion of abnormally differentiated blasts of myeloid lineage. As a result of this proliferation of immature myeloid cells include accumulation of immature progenitors (blasts) with impairment of normal hemopoiesis, leading to severe infections, anemia, and hemorrhage | [22] |
Chronic lymphocytic leukemia (CLL) | - A lymphoproliferative disorder which is characterized by monoclonal, mature CD5+ B cells expansion in the peripheral blood, secondary lymphoid tissues and bone marrow - It represents the most common type of leukemia in adults | [26] |
Chronic myeloid leukemia (CML) | - A myeloproliferative neoplasm with an incidence of 1–2 cases per 100 000 adults - Predominantly composed of granulocytes, it affects peripheral blood and bone marrow as well - The most common in older adults and men |