Table 1 Baseline characteristics
Variables | Total (n = 2725) | Non-statins | Statins | p |
|---|---|---|---|---|
(n = 1241) | (n = 1484) | |||
Number | ||||
Age(year) | 72 (64, 80) | 69 (61, 78) | 73 (67, 80) | < 0.001 |
Gender(male) | 1456 (53.4) | 643 (51.8) | 813 (54.8) | 0.121 |
Los-ICU | 5.5 ± 5.9 | 6.0 ± 6.4 | 5.1 ± 5.4 | < 0.001 |
Hospital days | 12.4 ± 10.2 | 12.9 ± 10.9 | 12.0 ± 9.7 | 0.013 |
Vitals | ||||
SBP (mmHg) | 117.0 ± 16.0 | 116.6 ± 15.6 | 117.4 ± 16.3 | 0.197 |
DBP (mmHg) | 61.9 ± 10.8 | 63.1 ± 11.0 | 60.9 ± 10.6 | < 0.001 |
HR (beats/min) | 85.9 ± 15.6 | 87.7 ± 16.4 | 84.4 ± 14.7 | < 0.001 |
RR (beats/min) | 19.8 ± 3.7 | 19.9 ± 3.9 | 19.8 ± 3.5 | 0.29 |
SpO2 (%) | 96.2 ± 2.3 | 96.2 ± 2.3 | 96.2 ± 2.2 | 0.826 |
Comorbidities, n (%) | ||||
Asthma | 114 ( 4.2) | 55 (4.4) | 59 (4) | 0.544 |
CAD | 456 (16.7) | 117 (9.4) | 339 (22.8) | < 0.001 |
CHF | 1216 (44.6) | 422 (34) | 794 (53.5) | < 0.001 |
PVD | 517 (19.0) | 168 (13.5) | 349 (23.5) | < 0.001 |
CVD | 433 (15.9) | 161 (13) | 272 (18.3) | < 0.001 |
Diabetes | 938 (34.4) | 315 (25.4) | 623 (42) | < 0.001 |
Liver disease | 314 (11.5) | 219 (17.6) | 95 (6.4) | < 0.001 |
Renal disease | 692 (25.4) | 215 (17.3) | 477 (32.1) | < 0.001 |
Malignant cancer | 446 (16.4) | 255 (20.5) | 191 (12.9) | < 0.001 |
Laboratory events | ||||
WBC(109/L) | 14.7 ± 11.2 | 15.0 ± 14.1 | 14.5 ± 8.0 | 0.249 |
HGB (g/L) | 11.3 ± 2.2 | 11.5 ± 2.3 | 11.3 ± 2.1 | 0.014 |
PLT (109/L) | 147.0 (119.0, 196.0) | 144.0 (118.0, 190.0) | 149.0 (120.0, 199.2) | 0.038 |
Glucose (mg/dL) | 209.0 (156.0, 277.0) | 206.0 (148.0, 284.0) | 210.5 (160.8, 272.0) | 0.184 |
Calcium (mg/dL) | 8.6 ± 0.7 | 8.6 ± 0.8 | 8.6 ± 0.7 | 0.047 |
Sodium (mmol/L) | 139.6 ± 4.9 | 139.5 ± 5.3 | 139.7 ± 4.6 | 0.342 |
Potassium (mmol/L) | 4.7 ± 0.9 | 4.7 ± 0.9 | 4.7 ± 0.8 | 0.553 |
Anion gap (mmol/L) | 16.4 ± 4.5 | 16.5 ± 4.7 | 16.3 ± 4.4 | 0.161 |
Treatment, n (%) | ||||
Glucocorticoid | 968 (35.5) | 483 (38.9) | 485 (32.7) | < 0.001 |
Antibiotic | 2280 (83.7) | 1073 (86.5) | 1207 (81.3) | < 0.001 |
Vasopressin | 284 (10.4) | 114 (9.2) | 170 (11.5) | 0.054 |
Norepinephrine | 575 (21.1) | 238 (19.2) | 337 (22.7) | 0.024 |
Epinephrine | 130 ( 4.8) | 56 (4.5) | 74 (5) | 0.563 |
ACEI/ARB | 416 (15.3) | 122 (9.8) | 294 (19.8) | < 0.001 |
β-blocker | 1437 (52.7) | 545 (43.9) | 892 (60.1) | < 0.001 |
VENT | 873 (32.0) | 387 (31.2) | 486 (32.7) | 0.383 |
Scores | ||||
CCI | 7.4 ± 2.6 | 7.0 ± 2.6 | 7.8 ± 2.5 | < 0.001 |
SAPII | 39.8 ± 12.8 | 40.4 ± 14.0 | 39.3 ± 11.6 | 0.023 |
OASIS | 34.3 ± 9.0 | 35.5 ± 9.4 | 33.3 ± 8.5 | < 0.001 |
Outcomes, n (%) | ||||
Delirium | 436 (16.0) | 237 (19.1) | 199 (13.4) | < 0.001 |
30-day mortality | 492 (18.1) | 269 (21.7) | 223 (15) | < 0.001 |