Fig. 3
From: The effects of apoptosis inhibitor of macrophage in kidney diseases
AIM in IgAN:AIM is stably associated with IgM by embedding the missing part of the hexagon in circulating blood. As for the binding mode of AIM to IgA in blood, it mostly binds to IgA–Fc through immunoprecipitation in mice, while the binding mechanism of AIM and IgA in humans is different from that in mice, which is speculated to be related to the abnormal glycosylation and glycosylation formation process of IgA1. We can confirm that IgA and IgM are linked via AIM, but the pathway by which IgG binds to AIM in immunoprecipitation is not clear