Table 3 Treatment characteristics of EWS patients
Variable | Unmatched | p-value | Propensity score (1:1) matched | p-value | ||
|---|---|---|---|---|---|---|
Patients ≤ 40 (n = 4058) | Patients > 40 (n = 542) | Patients ≤ 40 (n = 542) | Patients > 40 (n = 542) | |||
Surgery of primary site, n (%) | ||||||
 Surgery of primary site performed | 2102 (51.8) | 253 (46.7) | 0.025 | 268 (49.4) | 253 (46.7) | 0.362 |
 Surgery of primary site not performed | 1956 (48.2) | 289 (53.3) | 274 (50.6) | 289 (53.3) | ||
Surgical margins, n (%) | ||||||
 No residual tumor | 1456 (35.9) | 146 (26.9) | < 0.001 | 179 (33.0) | 146 (26.9) | 0.121 |
 Microscopic residual tumor | 96 (2.4) | 13 (2.4) | 14 (2.6) | 13 (2.4) | ||
 Macroscopic residual tumor | 47 (1.2) | 12 (2.2) | 5 (0.9) | 12 (2.2) | ||
 Surgical margins unknown | 96 (2.4) | 16 (3.0) | 15 (2.8) | 16 (3.0) | ||
Palliative care n (%) | ||||||
 Received | 168 (4.1%) | 42 (7.7%) | < 0.001 | 28 (5.2) | 42 (7.7) | 0.084 |
 Did not receive | 3890 (95.9%) | 500 (92.3%) | 514 (94.8) | 500 (92.3) | ||
Adjuvant therapy, n (%) | ||||||
 Adjuvant chemotherapy | 1826 (96.2%) | 198 (93.4%) | 0.039 | 234 (97.9) | 198 (93.4) | 0.017 |
 Adjuvant radiation | 14 (0.7%) | 5 (2.4%) | 0 (0.0) | 5 (2.4) | ||
 Adjuvant chemoradiation | 58 (3.1%) | 9 (4.2%) | 5 (2.1) | 9 (4.2) | ||
Time to surgery (mean days (SD)) | 99.0 (69.1) | 85.6 (89.7) | 0.005 | 102.4 (73.6) | 85.6 (89.7) | 0.020 |
Tumor size (mean mm (SD)) | 510.8 (455.6) | 525.7 (459.6) | 0.053 | 518.9 (455.2) | 525.7 (459.6) | 0.807 |
Time to initiation of treatment (mean days (SD)) | 19.2 (29.1) | 29.5 (36.7) | < 0.001 | 18.7 (24.8) | 29.5 (36.7) | < 0.001 |
Time to chemo (mean days (SD)) | 23.1 (28.4) | 46.3 (42.4) | < 0.001 | 22.8 (26.7) | 46.3 (42.4) | < 0.001 |