Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study

Table 2 MR results for the relationship between UC, CD and frailty index

Method	Number of SNPs	MR analysis			MR-Egger intercept p	Heterogeneity p
Method	Number of SNPs	Beta	95% CI	p	MR-Egger intercept p	Heterogeneity p
UC → FI
MR Egger	33	0.013	−0.013 to 0.041	0.333	0.979	0.134
Weighted median	33	0.015	0.004 to 0.026	0.007
IVW	33	0.014	0.006 to 0.021	0.001		0.163
Simple mode	33	0.028	0.004 to 0.051	0.032
Weighted mode	33	0.020	0.002 to 0.038	0.032
CD → FI
MR Egger	47	0.003	−0.011 to 0.017	0.676	0.170	0.070
Weighted median	47	0.005	−0.004 to 0.014	0.250
IVW	47	0.012	0.006 to 0.018	2e−04		0.054
Simple mode	47	0.007	−0.011 to 0.024	0.448
Weighted mode	47	0.005	−0.004 to 0.015	0.286

UC ulcerative colitis, CD Crohn’s disease, FI frailty index, IVW inverse variance weight, MR Mendelian randomization, SNP single nucleotide polymorphism

ISSN: 2047-783X