Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study

Table 3 MR results for the relationship between UC, CD, and sarcopenia

Method	Number of SNPs	MR analysis			MR-Egger intercept p	Heterogeneity p
Method	Number of SNPs	Beta	95%CI	p	MR-Egger intercept p	Heterogeneity p
UC → sarcopenia
MR Egger	35	0.011	−0.029 to 0.053	0.576	0.579	0.315
Weighted median	35	0.014	−0.010 to 0.037	0.263
IVW	35	0.001	−0.015 to 0.017	0.901		0.344
Simple mode	35	0.010	−0.035 to 0.055	0.675
Weighted mode	35	0.016	−0.019 to 0.051	0.375
CD → sarcopenia
MR Egger	50	−0.003	−0.030 to 0.025	0.851	0.668	0.191
Weighted median	50	0.005	−0.014 to 0.024	0.616
IVW	50	0.003	−0.009 to 0.015	0.656		0.214
Simple mode	50	0.004	−0.031 to 0.038	0.827
Weighted mode	50	0.005	−0.019 to 0.030	0.672

UC ulcerative colitis, CD Crohn’s disease, FI frailty index, IVW inverse variance weight, MR Mendelian randomization

ISSN: 2047-783X