Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study

Table 4 Bidirectional MR results for the relationship between UC, CD and frailty index

Method	No. of SNPs	MR analysis			MR-Egger intercept p	Heterogeneity p
Method	No. of SNPs	OR	95%CI	p	MR-Egger intercept p	Heterogeneity p
FI → UC
MR Egger	39	1.446	0.123 to 17.013	0.771	0.976	0.465
Weighted median	39	1.407	0.801 to 2.473	0.235
IVW	39	1.392	0.951 to 2.038	0.089		0.511
Simple mode	39	1.612	0.537 to 4.841	0.400
Weighted mode	39	1.639	0.586 to 4.586	0.353
FI → CD
MR Egger	35	1.118	0.017 to 74.697	0.959	0.940	0.003
Weighted median	35	0.623	0.316 to 1.228	0.171
IVW	35	0.952	0.538 to 1.687	0.868		0.004
Simple mode	35	0.226	0.028 to 1.840	0.174
Weighted mode	35	0.213	0.024 to 1.867	0.172

UC ulcerative colitis, CD Crohn’s disease, FI frailty index, IVW inverse variance weight, MR Mendelian randomization, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval

ISSN: 2047-783X