Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study

Table 5 Bidirectional MR results for the relationship between UC, CD, and sarcopenia

Method	No. of SNPs	MR analysis			MR-Egger intercept p	Heterogeneity p
Method	No. of SNPs	OR	95%CI	p	MR-Egger intercept p	Heterogeneity p
Sarcopenia → UC
MR Egger	21	0.941	0.352 to 2.515	0.905	0.906	0.371
Weighted median	21	1.017	0.730 to 1.415	0.922
IVW	21	0.998	0.796 to 1.250	0.984		0.433
Simple mode	21	1.240	0.677 to 2.273	0.494
Weighted mode	21	1.192	0.692 to 2.055	0.534
Sarcopenia → CD
MR Egger	19	0.438	0.114 to 1.681	0.245	0.382	0.252
Weighted median	19	0.741	0.515 to 1.067	0.107
IVW	19	0.799	0.604 to 1.059	0.118		0.259
Simple mode	19	0.605	0.318 to 1.152	0.143
Weighted mode	19	0.646	0.346 to 1.025	0.186

UC ulcerative colitis, CD Crohn’s disease, FI frailty index, IVW inverse variance weight, MR Mendelian randomization, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval

ISSN: 2047-783X