Fig. 7

GPS inhibited the tumor growth and metastasis in vivo. A Tumor volume, tumor weight (day 28) showed significant decrease in the GPS group compared with control group, without changing the body weight. B GPS showed no cytotoxicites in heart, liver, spleen, lung and kidney tissues. C GPS promoted the apoptosis of cancer cells in vivo. D IHC showed that GPS could down-regulate the expression of EGFR, p-PI3K and p-AKT proteins and inhibited the proliferation of cancer cells in vivo. E, F GPS induced pulmonary metastasis, and significant up-regulation of E-cadherin and down-regulation of N-cadherin (***P < 0.001)