Healthy control (n = 25) | BHT (n = 25) | MHT (n = 25) | P | |
---|---|---|---|---|
Gender (male/female) | 19/6 | 21/4 | 24/1 | 0.10 |
Age (years) | 42.48 ± 8.39 | 40.08 ± 10.43 | 36.32 ± 11.67 | 0.12 |
BMI (kg/m2) | 23.07 ± 1.68 | 29.24 ± 4.80c | 26.65 ± 4.40a | <0.01 |
SBP (mmHg) | 118.6 ± 4.7 | 147.5 ± 9.4c | 193.8 ± 19.0a,b | <0.01 |
DBP (mmHg) | 79.88 ± 4.02 | 92.00 (90.00–100.00)c | 114.36 ± 14.33a,b | <0.01 |
Uric acid | 274.84 ± 59.69 | 503.92 ± 116.81c | 508.56 ± 120.21a | <0.01 |
BUN (mmol/L) | 5.17 ± 1.64 | 7.53 ± 3.10 | 15.52 (12.15–22.89)a,b | <0.01 |
Scr (μmol/L) | 59.25 ± 11.37 | 132.00 (103.50–180.50)c | 390.00 (237.00–546.50)a,b | <0.01 |
eGFR (mL/min/1.73 m2) | 118.60 ± 22.74 | 57.67 ± 30.06c | 17.00 (8.20–30.00)a,b | <0.01 |
Elabela (ng/ml) | 6.29 ± 0.94 | 4.73 ± 1.25c | 3.82 ± 1.08a,b | <0.01 |
Histopathological | ||||
TAIF | – | 1.88 ± 0.78 | 2.63 ± 0.71 | <0.01 |
Intimal fibrosis | – | 1.00(1.00, 2.00) | 2.00(2.00, 2.00) | <0.01 |
Fibrinoid necrosis, n (%) | – | 0 | 9 (62.5) | <0.01 |
Myointimal cell proliferation, n (%) | – | 0 | 22 (91.7) | <0.01 |