Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling

Table 1 Relevance between TH protein expression and the clinical characteristics of individuals with hepatocellular carcinoma

Characteristic	Total	TH Expression		χ²	P
Characteristic	Total	Low (n=147)	High (n=51)	χ²	P
Age
≥55	182	135	47	0.005	0.604
<55	16	12	4	0.005	0.604
Gender
Male	68	59	9	8.493	0.002
Female	130	88	42	8.493	0.002
Tumor size
≥11	38	33	5	3.904	0.034*
<11	160	114	33	3.904	0.034*
Tumor number
≥2	24	22	2	4.336	0.026*
≤1	174	125	49	4.336	0.026*
PVTT
Yes	26	18	8	0.393	0.341
No	172	129	43	0.393	0.341
Tumor grade
I–II	48	35	13	2.898	0.235
III	150	112	38	2.898	0.235
HBV infection
Yes	88	61	27	2.009	0.105
No	110	86	24	2.009	0.105
AFP(μg/L)
≥400	84	69	15	6.291	0.043*
25~400	67	35	12
≤25	47	43	24
Paracancerous microtumor
Yes	70	49	21	1.019	0.2
No	128	98	30	1.019	0.2
Cirrhosis
Yes	186	141	45	3.926	0.048*
No	12	6	6	3.926	0.048*
Vascular tumor thrombus in cancer nest
Yes	84	63	21	0.044	0.484
No	114	84	30	0.044	0.484
Tumor capsular
Yes	115	86	29	0.042	0.482
No	83	61	22	0.042	0.482

ISSN: 2047-783X