Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches

Table 3 Genetic variants influencing NAFLD progression through cellular stress responses

Gene	Function	Variant	Mutation type	Variant classification	Population	References
IRGM	Modify hepatic lipophagy and mitophagy	rs10065172	Missense	Benign	Han Chinese	[120]
		rs10065172	Missense	Benign	Italian obese children	[121]
		rs13361189	Missense	Benign	American	[129]
SOD2	Protecting cells from oxidative stress	rs4880	Missense	Benign	Chinese	[112]
CAT	Detoxifies H₂O₂ in peroxisomes and mitochondria	rs1001179	Upstream variant	Benign	Chinese	[112]
GPX1	Reduce hydrogen peroxide to generate oxidized glutathione and water	rs1050450	Missense	Benign	Chinese	[112]
UCP3	Metabolism of superoxide radicals	rs3781907	Intronic variant	Benign	Brazilian	[130]
MTARC1	Metabolic processes in the liver	rs139321832	Stop	Likely Benign	American	[131]

UCP3 uncoupling protein 3, MTARC1 mitochondrial amidoxime reducing component 1

ISSN: 2047-783X