Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches

Table 4 Genetic variants associated with NAFLD progression by inflammatory signaling pathways

Gene	Function	Variant	Mutation type	Variant classification	Population	References
CNR2	Inflammation signaling regulator	rs35761398	Missense	Uncertain significance	Italian children	[154]
TNF-α	Proinflammatory cytokines; induces neutrophils to develop pyroptosis	rs1800629	Upstream variant	Benign	Iranian	[155]
IL-1β		rs16944	Upstream variant	Benign	Caucasian	[149]
IL-6		rs1800795	Upstream variant	Benign	Caucasian	[149]
IL-27	Central coordinator of Treg cell effector, functions during inflammation	rs4788084	Upstream variant	Benign	Indian	[63]
IL-27		rs2275913	Upstream variant	Benign	Turkish children	[156]
IL-13	Upregulates the expression of collagens and other pro-fibrotic genes	rs20541	Missense	Likely Benign	Caucasian	[157]
STAT6	PPARγ action modulator	rs167769	Intronic variant	Benign	Caucasian	[157]
IL-28B	Immune response	rs12979860	Intronic variant	Benign	Italian	[158]

IL-27 interleukin 27, IL-13 interleukin 13, STAT6 signal transducer and activator of transcription 6, IL-28B interleukin 28B

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