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Fig. 4 | European Journal of Medical Research

Fig. 4

From: Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT

Fig. 4

Circ-10720 modulates ZEB2 via sponge adsorption of miR-1238. A Detection of miR-1238 in NSCLC tissues and para-cancerous tissues by RT-qPCR; B prediction of the binding site of circ-10720 and miR-1238 by the bioinformatics website; C verification of binding of circ-10720 with miR-1238 by the dual luciferase; D test of endogenous association of miR-1238 with circ-10720 by RIP; E examination of the enrichment of miR-1238 to circ-10720 by RNA pull-down; F FISH showed that circ-10720 and miR-1238 were co-localized in the cytoplasm of A549 and HCC44 cells; red represents circ-10720 and green represents miR-1238; G detection of ZEB2 mRNA in NSCLC tissues and para-cancerous tissues by RT-qPCR; H prediction of the targeting of ZEB2 with miR-1238 by the bioinformatics website; I targeting of ZEB2 with miR-1238 detected by the dual luciferase reporter assay; *P < 0.05, **P < 0.01. N = 3; the data in the figure were in the form of mean ± SD

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