Fig. 4

Molecular docking. A Original crystal structure of the mTOR downloaded from Protein Data Bank (4JSV); B the monomer structure of mTOR; C the structure of mTOR with each domain marked by different colour; molecular docking for mTOR with moracin D (D), cerevisterol (E), (22e,24r)-ergosta-6-en-3beta,5alpha,6beta-triol (F), deoxyandrographolide (G), moracin O (H) and polyporusterone E (I), on the top shows the surface of the receptor protein and 3D structure of the ligand, at the bottom shows the detail binding bond of each ligand with receptor protein