Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity

Table 1 Results of heterogeneity and horizontal pleiotropy analysis

Bacterial taxa (exposure)	irAEs (outcome)	Heterogeneity test			Horizontal pleiotropy results
Bacterial taxa (exposure)	irAEs (outcome)	Cochran's Q	df	p value	Egger intercept	SE	p value
Lachnospiraceae	High-grade irAEs	5.18	12	0.95	0.04	0.11	0.73
Verrucomicrobiaceae	High-grade irAEs	4.18	7	0.76	0.36	0.61	0.57
Eubacterium (fissicatena group)	High-grade irAEs	0.33	4	0.99	0.07	0.53	0.9
Akkermansia	High-grade irAEs	4.18	7	0.76	0.37	0.61	0.56
Anaerostipes	High-grade irAEs	4.13	6	0.66	0.38	0.2	0.11
Collinsella	High-grade irAEs	0.82	6	0.99	− 0.19	0.23	0.43
Coprococcus3	High-grade irAEs	0.47	4	0.98	− 0.28	0.46	0.59
Ruminiclostridium6	High-grade irAEs	3.54	7	0.83	− 0.17	0.18	0.38
Lachnospiraceae	All-grade irAEs	17.3	12	0.14	0.09	0.11	0.43
Porphyromonadaceae	All-grade irAEs	0.66	4	0.96	0.05	0.28	0.87
Eubacterium (brachy group)	All-grade irAEs	1.41	5	0.92	− 0.11	0.29	0.73
DefluviitaleaceaeUCG011	All-grade irAEs	0.48	4	0.98	− 0.03	0.25	0.92
Peptococcus	All-grade irAEs	1.87	5	0.87	− 0.12	0.24	0.66
Roseburia	All-grade irAEs	3.75	7	0.81	− 0.31	0.22	0.21
RuminococcaceaeUCG004	All-grade irAEs	2.73	7	0.91	− 0.23	0.3	0.47

ISSN: 2047-783X