Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity

Table 2 Univariate MR estimates between common risk factors and irAEs

Exposures	Method	NSNP	Outcomes
			High-grade irAEs		All-grade irAEs
			Beta (95%CI)	p value	Beta (95%CI)	p value
Anthropometric factors
BMI	IVW	314	− 0.60 (− 1.34, 0.14)	0.11	− 0.74 (− 1.41, − 0.06)	0.03
Waist circumference	IVW	26	0.61 (− 1.01, 2.23)	0.46	0.05 (− 1.15, 1.24)	0.94
Waist circumference (adjusted for BMI)	IVW	46	0.00 (− 1.37, 1.38)	1.00	− 0.39 (− 1.5, 0.73)	0.50
Hip circumference	IVW	38	0.09 (− 0.92, 1.10)	0.86	− 0.63 (− 1.7, 0.44)	0.25
Hip circumference (adjusted for BMI)	IVW	52	0.65 (− 0.38, 1.69)	0.21	0.47 (− 0.52, 1.45)	0.35
Waist-to-hip ratio	IVW	20	− 0.28 (− 2.21, 1.64)	0.77	− 1.69 (− 3.56, 0.18)	0.08
Waist-to-hip ratio (adjusted for BMI)	IVW	25	0.84 (− 0.88, 2.55)	0.34	− 0.54 (− 1.94, 0.85)	0.44
Lifestyle factors
Alcoholic drinks per week	IVW	14	− 0.44 (− 4.21, 3.33)	0.82	− 0.06 (− 3.24, 3.12)	0.97
Cigarettes smoked per day	IVW	13	0.11 (− 0.93, 1.16)	0.83	0.67 (− 0.29, 1.63)	0.17
Smoking initiation	IVW	54	0.08 (− 1.21, 1.37)	0.90	− 0.10 (− 1.23, 1.04)	0.87
Type 2 diabetes	IVW	79	− 0.16 (− 0.48, 0.17)	0.34	0.01 (− 0.33, 0.34)	0.97

BMI body mass index, IVW Inverse variance weighted method, NSNP number of SNPs, irAEs immune-related adverse events, 95% CI 95% confidential interval, High-grade irAEs, grade 3–5 irAEs

ISSN: 2047-783X