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Table 3 Multivariable MR estimates between Lachnospiraceae, BMI and irAEs

From: Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity

Exposures in MVMR

Outcomes

High-grade irAEs

All-grade irAEs

Beta (95% CI)

p value

Beta (95% CI)

p value

Lachnospiraceae

− 0.91 (− 1.84, 0.01)

0.05

− 1.07 (− 1.96, − 0.18)

0.02

BMI

− 0.43 (− 1.2, 0.34)

0.28

0.01 (− 0.33, 0.34)

0.34

  1. MVMR multivariable MR analysis, BMI body mass index, irAEs immune-related adverse events, 95% CI 95% confidential interval, High-grade irAEs, grade 3–5 irAEs
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European Journal of Medical Research

ISSN: 2047-783X

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