Table 3 Pooled HRs of overall survival of patients with increased SNHG5 expression
Subgroup analysis | Number of studies | Number of patients | Pooled HR(95%CI) | I2(%) | P-value | Model | |
|---|---|---|---|---|---|---|---|
Fix effect model | Random effect model | ||||||
OS | 7 | 425 | 1.33 (1.00–1.77) | 1.90 (0.87–4.15) | 85 |  < 0.00001 | Random |
Tumor type | |||||||
 Digestive system | 4 | 262 | 0.97 (0.67–1.41) | 1.45 (0.42–4.96) | 90 |  < 0.00001 | Random |
 Non-digestive system | 3 | 163 | 2.06 (1.32–3,20) | 2.54 (1.18–5.48) | 53 | 0.12 | Random |
Analysis method | |||||||
 Univariate analysis | 5 | 327 | 1.02 (0.75–1.40) | 1.31 (0.58–2.99) | 84 |  < 0.0001 | Random |
 Multivariate analysis | 2 | 98 | 4.84 (2.42–9.70) | 4.84 (2.42–9.70) | 0 | 0.97 | Fixed |
Cut-off value | |||||||
 Mean | 1 | 67 | 2.82 (1.13–7.04) | 2.82 (1.13–7.04) | – | – | – |
 Median | 6 | 358 | 1.23 (0.91–1.65) | 1.79 (0.74–4.30) | 87 |  < 0.00001 | Random |
HR statistics | |||||||
 Paper | 2 | 98 | 4.84 (2.42–9.70) | 4.84 (2.42–9.70) | 0 | 0.97 | Fixed |
 Survival curve | 5 | 327 | 1.02 (0.75–1.40) | 1.31 (0.58–2.99) | 84 |  < 0.0001 | Random |
Number of patients | |||||||
 Not less than 60 | 4 | 295 | 0.93 (0.68–1.29) | 0.99 (0.45–2.18) | 83 | 0.0006 | Random |
 Less than 60 | 3 | 130 | 5.23 (2.78–9.83) | 5.23 (2.78–9.83) | 0 | 0.87 | Fixed |
Follow-up (month) | |||||||
 Not less than 60 month | 4 | 295 | 1.11 (0.76–1.62) | 1.19 (0.42–3.42) | 86 | 0.0008 | Random |
 Less than 60 month | 3 | 130 | 1.70 (1.09–2.63) | 2.95 (0.75–11.64) | 87 |  < 0.0001 | Random |
 DFS | 1 | 48 | 3.690 (1.229–11.082) | 3.690 (1.229–11.082) | – | – | – |