Clinicopathologic characteristics | No. of studies | No. of patients | Odds ratio (95% CI) | Heterogeneity | ||
---|---|---|---|---|---|---|
Fixed | Random | I2(%) | P-value | |||
Age | 11 | 801 | 0.96 (0.71–1.29) | 0.96 (0.71–1.30) | 0 | 0.9 |
Gender | 7 | 443 | 0.74 (0.49–1.12) | 0.76 (0.46–1.25) | 25 | 0.35 |
 TNM (III + IV vs. I + II) | 10 | 748 | 3.78 (2.75–5.19) | 4.12 (2.62–6.46) | 43 | 0.07 |
  Digestive system | 6 | 446 | 4.50 (2.98–6.8) | 4.49 (2.96–6.81) | 0 | 0.59 |
Reproductive system | 3 | 262 | 2.36 (1.38–4.03) | 2.79 (1.04–7.48) | 59 | 0.09 |
  Other system | 1 | 40 | 16.00 (3.23–79.27) | 16.00 (3.23–79.27) | – | – |
 LNM (present vs. absent) | 8 | 638 | 2.16 (1.56–2.99) | 2.16 (0.97–4.80) | 80 |  < 0.0001 |
  Digestive system | 5 | 376 | 2.24 (1.48–3.38) | 2.13 (0.59–7.64) | 87 |  < 0.0001 |
Non-digestive system | 3 | 262 | 2.03 (1.20–3.44) | 2.12 (0.85–5.27) | 64 |  < 0.0001 |
 Tumor size | 7 | 490 | 3.10 (2.13–4.50) | 3.23 (2.07–5.03) | 24 | 0.24 |
  Digestive system | 4 | 228 | 4.11 (2.34–7.21) | 4.11 (2.33–7.26) | 0 | 0.55 |
  Non-digestive system | 3 | 262 | 2.47 (1.50–4.08) | 2.67 (1.26–5.64) | 51 | 0.13 |
 Histological grade | 6 | 498 | 1.85 (1.29–2.67) | 1.84 (1.25–2.70) | 7 | 0.37 |
  Digestive system | 5 | 376 | 1.95 (1.28–2.98) | 1.96 (1.18–3.26) | 23 | 0.27 |
  Non-digestive system | 1 | 122 | 1.59 (0.77–3.27) | 1.59 (0.77–3.27) | – | – |
 DM (present vs. absent) | 3 | 296 | 4.61 (2.53–8.39) | 4.11 (2.23–7.58) | 0 | 0.4 |
 Depth of invasion | 2 | 190 | 1.46 (0.83–2.58) | 1.78 (0.35–9.00) | 85 | 0.009 |