Table 5 Some molecular biological mechanisms of SNHG5 regulating cancer progression
Author | Year | Cancer type | Level of expression | MicroRNA | Gene | Function |
|---|---|---|---|---|---|---|
Ma | 2018 | Bladder cancer | Upregulated | – | p27, caspase-3, caspase-9, CDK2 | Induce proliferation, inhibit apoptosis |
Wang | 2018 | Lung adenocarcinoma | upregulated | miR-377 | CASP1 | Gefitinib resistance |
Li | 2018 | HCC | Upregulated | miR-26a-5p | GSK3β and Wnt/β-catenin signal pathway | Contributed to the proliferation and migration |
Yan | 2022 | HCC | Upregulated | – | SPATS2 | Induce the proliferation and migration |
Zhang | 2021 | CC | Upregulated | miR-132 | SOX4 | Accelerate CC cell proliferation, migration and invasion |
Wang | 2018 | osteosarcoma | Upregulated | miR-26a | ROCK1 | Accelerate the migration, invasion and proliferation, inhibit apoptosis |
Liu | 2020 | NCC | Upregulated | miR-1179 | HMGB3 | Drive cell proliferation, migration and invasion |
Ying | 2020 | AML | Upregulated | miR-489-3p | SOX4 | Contributed to the proliferation and inhibit the apoptosis |
Wei | 2021 | esophageal cancer | Upregulated | – | MTA2 | Inhibit the EMT process |
2022 | DLBCL | Upregulated | miR-181-5p | XIAP | Accelerated the proliferation, migration, and invasion |