A non-linear connection between the total cholesterol to high-density lipoprotein cholesterol ratio and stroke risk: a retrospective cohort study from the China Health and Retirement Longitudinal Study

Table 3 Relationship between TC/HDL-C ratio and the incident stroke in different models

Exposure	Model 1 (HR.,95% CI, P)	Model 2 (HR,95% CI, P)	Model 3 (HR,95% CI, P)
TC/HDL-C ratio (per 1 increase)	1.14 (1.09, 1.19) < 0.0001	1.08 (1.04, 1.13) 0.0003	1.05 (1.00, 1.10) 0.0402
TC/HDL-C ratio (quartile)
Q1	Ref	Ref	Ref
Q2	1.28 (1.08, 1.53) 0.0050	1.21 (1.01, 1.44) 0.0360	1.21 (1.02, 1.44) 0.0319
Q3	1.38 (1.17, 1.64) 0.0002	1.24 (1.04, 1.47) 0.0161	1.25 (1.04, 1.48) 0.0145
Q4	1.63 (1.38, 1.93) < 0.0001	1.36 (1.14, 1.61) 0.0005	1.23 (1.02, 1.47) 0.0258
P for trend	< 0.0001	0.0008	0.0384

Model 1: we did not adjust for other covariants
Model 2: we adjusted for age, gender, educational attainment, annual income, smoking status, drinking status, physical activity, and BMI
Model 3: we adjusted for age, gender, educational attainment, annual income, smoking status, drinking status, physical activity, BMI, CHD, CLD, liver disease, CRP, WBC, Scr, Cystatin C, hemoglobin, FPG, HbA1c, lipid-lowering medication, antihypertensive medication, and glucose-lowering medication
HR hazard ratios, CI confidence interval, Ref reference, TC/HDL-C ratio total cholesterol to high-density lipoprotein cholesterol ratio

ISSN: 2047-783X